The healing optic nerve in glaucoma: transforming growth factor beta and optic nerve head remodelling
نویسندگان
چکیده
منابع مشابه
Transforming growth factor beta isoforms in human optic nerve heads.
AIM To determine if the isoforms of transforming growth factor beta (TGF-beta) are present in fetal, normal adult, and glaucomatous optic nerve heads. METHODS To localise cells synthesising TGF-beta, optic nerve heads were stained using antibodies to TGF-beta 1, TGF-beta 2, and TGF-beta 3. To demonstrate synthesis, human optic nerve heads from fetal, glaucomatous, and normal age matched subje...
متن کاملThe optic nerve head in myocilin glaucoma.
PURPOSE Approximately 1 in 30 unselected patients with open-angle glaucoma (OAG) have a mutation in the myocilin gene. The purpose of this study was to describe the morphologic features of the optic nerve head (ONH) in myocilin glaucoma. METHODS A case-control design was adopted. Sixty-six patients heterozygous for a range of myocilin mutation (cases) were matched in disease severity to 105 p...
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The ONH can be examined using a direct ophthalmoscope, an indirect ophthalmoscope, or a posterior pole lens with a slit lamp. Many types of health professional can assess the ONH accurately after having appropriate training. Dilating the pupil makes this easier and will improve the accuracy of the examination, regardless of which instrument is used. Where the equipment is available, more sophis...
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These days it is commonly accepted that multiple factors are involved in the etiology of glaucoma. Although many studies have demonstrated that the major risk factor for glaucoma is an increase in intraocular pressure (IOP), some studies, including epidemiologic studies, have suggested an association between glaucoma, especially primary open-angle glaucoma (POAG) and normal-tension glaucoma (NT...
متن کاملOptic nerve head drusen and glaucoma.
The simultaneous occurrence of both optic nerve head drusen and glaucoma may make it difficult to evaluate visual field defects and the appearance of the optic nerve head. We saw five patients with both conditions, of whom four had pigmentary glaucoma or pigmentary dispersion syndrome. Drusen do not preclude the development of cupping, and they make it difficult to interpret its significance. M...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1999
ISSN: 0007-1161
DOI: 10.1136/bjo.83.2.132